As All-for-One said in Deku's dream: The Quirk Singularity, as defined as "the point in time at which quirks are no longer controllable" as already come to pass. We can see this in the cases of Shigaraki, Eri, and Toga. But I believe there are three more Singularities or "Genome Shifts" that have yet to occur:
1. The Unmutification
Eventually there will be a shapeshifting quirk that allows mutants to look normal. Once this gene is passed around enough everyone will look human again. This gene will be highly sought ought by mutant parents because being a mutant sucks. Maybe it will evolve out of the Transformation Quirk branch or is even already possible with selective Quirk Breeding between mutants and Transformers. My point is that eventually mutants will dissapear from the human phenotype and everyone who would have been a mutant will simply have the ability to transform into a mutant.
2. The Telekinetic Revolution
We've already seen two people with telekinetic quirks. Once variations of the TK gene mix with enough other quirks, people will have the ability to activate their quirks from a distance. e.g. 1. instead of Bakugo's descendents making explosions with their hands, they'll think and place an explosion some distance from them 2. instead of Ochacho's descendents making things weightless with their hands, they'll point at something and it will become weightless. At this point humanity will be like gods and enforcing the ban on public quirk usage would be much more difficult. e.g. Q: "Who made that fire hydrant explode?!" A: "I don't know , nobody was touching it."
3. The Creatification
Tamashiro can create little Chain-Chomps with mouths and Fumikage's Dark Shadow can talk. Before long, people will have quirks that can create automotons that can talk and think and hopefully follow orders. Work will become a thing of the past as people create droids out of their quirk to do their every bidding.
I believe that the next 3 genome shifts will occur in this order and I believe that shapeshifting/transformation quirks, telekinetic quirks, and sentience-granting are going to be the three most important quirks in this timeline.
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