Yes. For a side project a few years ago, tried making a game for blind people. Used fmod and some shitty webcam mocap to track head +arm. The blind player would point their arm where the sound was coming from and open their hand to shoot.
Turns out, we all sucked too much at coding at the time to make it work well, and even then half of us had such bad hearing acuity that they couldn't play.
Tldr yes, but it's hard to do right and you'll want help from acoustic engineers instead of fellow noobs
I'm interested to see if anyone has done anything like this. There's a lot of overhead, all things considered