Talk to all the NPCs around town, remember never to equip a sword that you haven't identified (this game likes to screw you with un-unequippable items), if you get an idea sephera (glowing white thing) toss it at the Baroquemonger for some dialogue about the thing. Be on the lookout for NPCs in the tower, if you see a robot that looks like two masks on a roomba sort of deal (just rolling around with the masks spinning) throw all your shittiest items at it and hope it spits out something useful. Some enemies are better off run from, like the monkey looking fucks, they can steal anything from your inventory. If you get far enough down the tower you'll find YUGE balls, toss your best items into it and hatboy will have it next incarnation. If you see a flame trap, and for some reason you want a heart to become a burnt heart, you can toss it on the flame trap and it'll burn the heart, changing it's properties (removing all previous ones and replacing them with burnt). When you get to tougher enemies remember tossing shit at them is a viable strat. Give Long Neck the cultivation serum and things start getting interesting. That's all the advice I remember.