Here, I'm gonna outline a plot of what would make a GOOD rampage movie.
>Start with the basis of World tour: Two employees, man and woman, working at Scumlabs
>they think it's just chemical and medical storage
>during an accidental messup during transport, see a dude mutate into some creature and get killed by the security forces
>the two employees decide they will have to leak this to the press, but are trying to act cool
>boss realizes they know too much and arrange an accidental explosion at a plant
>they don't die and instead, start to mutate
>george and lizzie are trying to keep their heads on, but can't stop accidentally destroying things
>eventually just get pissed and start smashing things, deciding to go after Scum labs since they can at least make sure no one else gets mutated
>only people eaten and killed are the Scum labs scientists and the Scum Labs private military, though a lot of landmarks and stuff are destroyed
>midway through the mayhem, Scum Labs boss announces a project to stop the monsters and transforms one of his soldiers into a monster
>reveals the monster mostly retains the human brain, but has some vicious tendencies
>sends Ralph to fight George and Lizzie
>he does a damn good job of it since he has combat training and the other two are just basically janitors
>they eventually convince Ralph that he's just an asset and he'll be experimented on once he's done his job and he won't ever get to be human again
>Ralph agrees that Scum Labs needs to be toast
>commence road trip of the three monsters trashing places (even posing in front of monuments with tourists before destroying them)
>fighting Scum Labs military along the way
>eventually reach the main CEO building
>big boss guy decides he's gonna fight fire with fire and has saved the bet serum for last
>Becomes Vern and mostly beats the shit out of the other monsters
>when he loses his marbles to the rampage, he goes off the deep end
>george lizzie and ralph also try to tell him he's bananas and will just be a test subject
>says he'll rule the world instead
>point out during their fight that the four of them totaled the last Scum Lab plant along with the cure
>gives them a moment to gang up on him and overpower him
>sexy assistant lady who was keeping tabs on the monsters uses an experimental device to KO the monsters and then the plans for the monsters being shipped across the world to be contained is the closing of the film
>this would let us go right into a Universal Tour opening should a second movie start
I feel this lets us sympathize with the monsters and lets the plot get as serious or stupid as we want as well as a big excuse for nutty mayhem.