/fit/ - Fitness, Health, Exercise, Dieting, etc

It is important to lower edema (water retention) so that swelling which exacerbates the situation is reduced. Estrogens cause cells to fill with water, and estrogen antagonists such as thyroid hormones, progestogens, and androgens all work to combat the swelling effects and reverse sagging caused by estrogenic influences. High fat diets increase estrogen (Hilakivi-Clarke, 1996), and high carbohydrate diets maintain (Eales, 1988) and stimulate (Young, 1980) thyroid hormone production which will ultimately help keep swelling at bay. Connective tissues which hold things in place, prevent sagging, and give the body structure have significant amounts of collagen which contains glycine—an amino acid which is only available in limited amounts in a typical modern Western diet. Glycine may be obtained as a supplement or through consumption of gelatin or gelatinous meats, and it is potentially helpful as collagen is being continually replace throughout life. (Neuberger, 1953) Hernias have been viewed as a failure of collagen maturation (Wirtschafter, 1964; Wagh 1972), which I would assume is exacerbated by a diet lacking nutrients for efficient collagen production, such as vitamin C—depletion of which is known factor in hernias (Bartlett, 1942).

>>139948

Hilakivi-Clarke, Leena, Elizabeth Cho, and Ighovie Onojafe. High-fat diet induces aggressive behavior in male mice and rats. Life sciences 58.19 (1996): 1653-1660.

https://doi.org/10.1016/0024-3205(96)00140-3

>The animals were assigned to two groups including those consuming a diet high in polyunsaturated fats (43% calories from fat) and those consuming a lowfat diet (16% calories from fat). […] Serum levels of estradiol (E2) were elevated by 2-fold in the male animals consuming a high-fat diet, when compared with the male animals kept on a low-fat diet. These findings suggest that dietary fat can increase aggressive behavior in male mice and rats, possibly by elevating circulating E2 levels.

Eales, J. Geoffrey. The influence of nutritional state on thyroid function in various vertebrates. American Zoologist 28.2 (1988): 351-362.

https://doi.org/10.1093/icb/28.2.351

>Predominant amongst the thyroid changes is a consistent alteration in peripheral T3, production due to regulation of hepatic T4 5′-monodeiodinase activity, which causes decreased T3 blood levels in caloric- (mainly carbohydrate) deficient states.

Young, Ruth A., Orien L. Tulp, and Edward S. Horton. Thyroid and growth responses of young Zucker obese and lean rats to a low protein-high carbohydrate diet. The Journal of nutrition 110.7 (1980): 1421-1431.

https://doi.org/10.1093/jn/110.7.1421

>Experiments were conducted to study the effects of a low protein-high carbohydrate diet on growth and thyroid function in obese and lean male and female Zucker rats. […] The relative hyperphagia, decreased efficiency of energy utilization and increased oxygen consumption and serum T3 concentrations in the lean rats fed the low-protein diet were consistent with the development of an adaptive thermogenesis, allowing the excess nonprotein energy to be dissipated through excess heat production. There was no evidence for such an adaptive thermogenesis in the obese rats.

Neuberger, A., and H. G. B. Slack. The metabolism of collagen from liver, bone, skin and tendon in the normal rat. Biochemical Journal 53.1 (1953): 47.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1198099/

>Subject to the limitations mentioned the results suggest that, even in the adult rat, collagen fibres are continually, but very slowly, replaced, the turnover rates being highest for collagen from bone. It is likely that in young rats this change is somewhat faster. However, in all age groups all collagens showed turnover rates which are low compared with those of intracellular proteins.

Wirtschafter, Zolton T., and J. Peter Bentley. Hernias as a collagen maturation defect. Annals of surgery 160.5 (1964): 852.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1408836/

Wagh, Premanand V., and Raymond C. Read. Defective collagen synthesis in inguinal herniation. The American Journal of Surgery 124.6 (1972)': 819-822.

https://doi.org/10.1016/0002-9610(72)90148-1

>From these observations it is suggested that the cause of herniation in the adult lies in a reduced collagen synthesis by the fibroblasts, thus rendering the abdominal aponeuroses weaker.

.

Boyera, N., I. Galey, and B. A. Bernard. Effect of vitamin C and its derivatives on collagen synthesis and cross‐linking by normal human fibroblasts. International Journal of Cosmetic Science 20.3 (1998): 151-158.

https://doi.org/10.1046/j.1467-2494.1998.171747.x

>It was shown that VitC induced a dose‐dependent increase in collagen type I deposits by normal human fibroblasts (NHF) cultured in monolayer, and enhanced extracellular matrix contraction by NHF in a lattice model, in a non‐cytotoxic range of concentrations (103m, 104m, 105m). Exogenous VitC supply could thus contribute to the maintenance of optimal collagenic density in the dermis and locally strengthen the collagen network.

Bartlett, Marshall K., Chester M. Jones, and Anna E. Ryan. Vitamin C and wound healing: II. Ascorbic acid content and tensile strength of healing wounds in human beings. New England Journal of Medicine 226.12 (1942): 474-481.

https://doi.org/10.1056/NEJM194203192261202

>>139949

An additional noteworthy article I just found:

Franz, Michael G. The biology of hernia formation. Surgical Clinics of North America 88.1 (2008): 1-15.

https://doi.org/10.1016/j.suc.2007.10.007

https://sci-hub.tw/10.1016/j.suc.2007.10.007

>Several vitamin and mineral deficiencies also have been described that predispose to altered wound repair. Vitamins C, A, and B6 each are required for collagen synthesis and cross-linking. Deficiencies in vitamins B1 and B2 as well as zinc and copper cause syndromes associated with poor wound repair.

Be well nourished and avoid the stretching and sagging of tissues associated with bloatedness.

>>139950

Ah, I suppose a hernia has no chance of rectifying itself?

>>139955

It's hard to say. Many things can rectify themselves. Bones can heal quite well, but few would dare to allow a broken arm to heal completely on its own without first straightening it back out into a normal position. I don't know what your hypothetical hernia looks like inside you. Something may have torn, or alternatively things have been stretched like a worn out elastic band in a fat man's briefs after Thanksgiving. Tissues that have been stretched or sagged can often be recovered through administration of the right hormones—generally progestogens, androgens, and thyroid hormones—as can those that have been swollen. T3 or pregnenolone are a reasonable choices as they both have this property of stimulating production or converting to the hormone you need in a given context. Fat soluble vitamins A, D, E, and K all oppose estrogenic influences as well.

You really want to get any swelling down to keep the circulation up in the testes. With continued free flow of blood, you buy time to either wait and see what happens, casually schedule surgical hernia correction, or investigate your own remedies. Aspirin—not to be confused with acetaminophen, paracetamol, or Tylenol™—might be a sensible choice in the short term. Acutely restricted circulation to the testes can become a medical emergency required surgery before tissues succumb to hypoxia. You should know by the pain if it becomes that serious, however.

Moncada, S., S. H. Ferreira, and J. R. Vane. Prostaglandins, aspirin-like drugs and the oedema of inflammation. Nature 246.5430 (1973): 217.

https://doi.org/10.1038/246217a0

Smith, M. J. H., A. W. Ford‐Hutchinson, and P. N. C. Elliott. Prostaglandins and the anti‐inflammatory activities of aspirin and sodium salicylate. Journal of Pharmacy and Pharmacology 27.7 (1975): 473-478.

https://doi.org/10.1111/j.2042-7158.1975.tb09487.x

>>139957

Oh yeah, be doubly sure to take additional vitamin C when taking aspirin. This is why:

Basu, T. K. Vitamin C-aspirin interactions. International journal for vitamin and nutrition research. Supplement= Internationale Zeitschrift fur Vitamin-und Ernahrungsforschung. Supplement 23 (1982): 83-90.

https://europepmc.org/abstract/med/6811490

In the human study, the concentrations of vitamin C in plasma, leucocytes and urine were found to be markedly elevated at various intervals following administration of a single oral dose of 500 mg of the vitamin. The vitamin C-associated increases, however, appeared to be blocked when the vitamin was given simultaneously with aspirin (900 mg). Similar findings were observed in guinea-pigs, where in addition faecal excretion of vitamin C was found to be significantly increased when the vitamin was administered together with aspirin. These results suggest that aspirin may impede gastrointestinal absorption of vitamin C.

>>139958

And if surgery were to occur, be sure to inform the doctors about any aspirin you've been taking, because aspirin increases bleeding by thinning the blood.

>>139958

>>139957

Thanks, there isn't any severe pain, just slight discomfort and a full feeling. I'm pretty sure I have a hernia, but I'm going to have a a doctor check it out this week. In the mean time, no lifting, and I'll pop some aspirin and absorbic acid until I see them.

Oh look, Captain Dunning-Kruger is at it again.

>>139946

I never understood what a hernia is. Your guts fall into your ballsack from lifting too hard?

>>140090

Not necessarily into your nutsack, but yes. You abdominal wall or pelvic floor will stop holding in your guts properly, and your intestines will pop out into somewhere they shouldn't go.