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H Saadat, Seyyed, Khodabakhsh Ahmadi, and Younes Panahi. The effect of on-demand caffeine consumption on treating patients with premature ejaculation: a double-blind randomized clinical trial. Current pharmaceutical biotechnology 16.3 (2015): 281-287.
https://doi.org/10.2174/1389201016666150118133045
>Intravaginal ejaculation latency time (IELT) and index of sexual satisfaction (ISS) were measured before and after treatment in both groups. […] Our study demonstrates that 100mg on-demand caffeine can significantly increase both IELT and ISS.
El‐Nashaar, AbdelRahman, and Rany Shamloul. EJACULATORY DISORDERS: Antibiotic Treatment Can Delay Ejaculation in Patients with Premature Ejaculation and Chronic Bacterial Prostatitis. The journal of sexual medicine 4.2 (2007): 491-496.
https://doi.org/10.1111/j.1743-6109.2006.00243.x
>Premature ejaculation (PE) is regarded as the most common male sexual disorder. Previous studies reported that prostatic inflammation was highly prevalent in PE. However, the effect of antibiotic treatment of cases with PE and chronic prostatitis has not been extensively investigated. […] Successful eradication of causative organisms in patients with PE and chronic prostatitis may lead to marked improvement in intravaginal ejaculatory latency time and ejaculatory control.
I keep reading things about histamine and serotonin being factors in premature ejaculation, but I am failing to find single definitive studies at the moment.