>>138745
>>138747
>>138748
If you can't find A2 milk or an alternative such as goat milk, coffee can somewhat alleviate opiate effects—perhaps mild constipation—associated with Bovine β-casomorphin 7 or alternatively those associated with wheat gluten consumption. Occasional use of an antihistamine such as cyproheptadine could counteract some of the histaminergic effects.
• Kurek, M., et al. A naturally occurring opioid peptide from cow’s milk, beta-casomorphine-7, is a direct histamine releaser in man. International archives of allergy and immunology 97.2 (1992): 115-120.
☞ https://doi.org/10.1159/000236106
• Fukudome, Shin-ichi, and Masaaki Yoshikawa. Opioid peptides derived from wheat gluten: their isolation and characterization. FEBS letters 296.1 (1992): 107-111.
☞ https://doi.org/10.1016/0014-5793(92)80414-C
• Boublik, J. H., et al. Coffee contains potent opiate receptor binding activity. Nature 301.5897 (1983): 246.
☞ https://doi.org/10.1038/301246a0
>We report here that instant coffee powders from a variety of manufacturers compete with tritiated naloxone for binding to opiate receptors in the rat brain membrane preparations, with no significant difference between normal and decaffeinated coffee. The receptor binding activity resembles that seen with opiate antagonists, in that there was no change in the half-maximal effective dose (ED50) in the presence of 100 mM Na+; on bioassay, the activity was similarly shown to be antagonistic and specific for opiate-induced inhibition of twitch.
• De Paulis, Tomas, et al. 4-Caffeoyl-1, 5-quinide in roasted coffee inhibits [3 H] naloxone binding and reverses anti-nociceptive effects of morphine in mice. Psychopharmacology 176.2 (2004): 146-153.
☞ https://doi.org/10.1007/s00213-004-1876-9
>These results suggest that the previously reported anti-opioid activity of instant coffee is caused primarily by the presence of 4-CQL, and to lesser extent by other cinnamoyl-1,5-quinides.
• Guzzo, Luciana S., et al. Cafestol, a coffee‐specific diterpene, induces peripheral antinociception mediated by endogenous opioid peptides. Clinical and Experimental Pharmacology and Physiology 39.5 (2012): 412-416.
☞ https://doi.org/10.1111/j.1440-1681.2012.05689.x
• Wanderer, Alan A., and Elliot F. Ellis. Treatment of cold urticaria with cyproheptadine. Journal of Allergy and Clinical Immunology 48.6 (1971): 366-371.
☞ https://doi.org/10.1016/0091-6749(71)90083-2