<“Whether weak or strong, the estrogenic response of a chemical, if not overcome, will add extra estrogenic burden to the system. At elevated doses, natural estrogens and environmental estrogen-like chemicals are known to produce adverse effects. The source of extra or elevated concentration of estrogen could be either endogenous or exogenous. The potential of exposure for humans and animals to environmental estrogen-like chemicals is high.”
D. Roy, et al., 1997
Natural Estrogens
Oncol Rep 1998 May-Jun;5(3):609-16 Maternal genistein exposure mimics the effects of estrogen on mammary gland development in female mouse offspring.
>Some phytoestrogens, such as genistein which is a major component in soy-based foods, and zearalenone, a mycotoxin found in agricultural products, have estrogenic effects on the reproductive system, breast and brain.
…
>Thus, our results suggest that genistein acts as an estrogen in utero, and may increase the incidence of mammary tumors if given through a pregnant mother.
Potential adverse effects of phytoestrogens. Whitten PL; Lewis C; Russell E; Naftolin F Department of Anthropology, Emory University, Atlanta, GA 30322. J Nutr, 1995 Mar, 125:3 Suppl, 771S-776S
>Our investigations have examined the effects of a range of natural dietary concentrations of the most potent plant isoflavonoid, coumestrol, […] In contrast, the 10-day coumestrol treatments produced significant deficits in the sexual behavior of male offspring.
Proc Soc Exp Biol Med 1995 Jan;208(1):6-12 Chemical studies of phytoestrogens and related compounds in dietary supplements: flax and chaparral.
>Flaxseed contains high levels of phytoestrogens. Chaparral has been associated with acute nonviral toxic hepatitis and contains lignans that are structurally similar to known estrogenic compounds.
"Stimulatory influence of soy protein isolate on breast secretion in pre- and postmenopausal women,"
>Instead, this pilot study indicates that prolonged consumption of soy protein isolate has a stimulatory effect on the premenopausal female breast, characterized by increased secretion of breast fluid, the appearance of hyperplastic epithelial cells, and elevated levels of plasma estradiol. These findings are suggestive of an estrogenic stimulus from the isoflavones genistein and daidzein contained in soy protein isolate.
[The effects on the thyroid gland of soybeans administered experimentally in healthy subjects]
>Hypometabolic symptoms (malaise, constipation, sleepiness) and goiters appeared in half the subjects in groups 2 and 3 after taking soybeans for 3 months, but they disappeared 1 month after the cessation of soybean ingestion. These findings suggested that excessive soybean ingestion for a certain duration might suppress thyroid function and cause goiters in healthy people, especially elderly subjects.
Cancer Res 1987 Mar 1;47(5):1333-8. Effects of dietary fats and soybean protein on azaserine-induced pancreatic carcinogenesis and plasma cholecystokinin in the rat.
>This study demonstrates that certain plant proteins enhance the growth of carcinogen-induced pancreatic foci and that this effect is considerably greater than the enhancement by high levels of dietary unsaturated fat. Furthermore, the enhancement by the raw soy protein isolate may be mediated by CCK; but this does not appear to be the mechanism by which the unsaturated fat, corn oil, enhances pancreatic carcinogenesis.
Environ Health Perspect 1997 Apr;105 Suppl 3:633-6 Dietary estrogens stimulate human breast cells to enter the cell cycle.
>"Our findings are consistent with a conclusion that dietary estrogens at low concentrations do not act as antiestrogens, but act like DDT and estradiol to stimulate human breast cancer cells to enter the cell cycle."
http://raypeat.com/articles/articles/natural-estrogens.shtml
The pros and cons of phytoestrogens
>A recent prospective study in human infants observed that female infants on soy-based infant formulas exhibit estrogenized vaginal epithelium at times when their breast fed or cow based formula counterparts did not, suggesting estrogenic activity of the soy infant formula [28].
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074428/