Toonstruck comes to mind. Point-and-click adventury stuff.
Christopher Lloyd gets stuck in a cartoon world and does adventury things. Decent writing, a loaded cast of recognizable and very pleasant voice actors you might know from animated shows from back in the day, humor's got some real bite here and there, and is pretty good on the whole. It has its bullshit moments in terms of puzzles, though. Some are cartoon gags that might give you trouble if you're not adjusted to it, sometimes reaching a little too far, others are just bad. Real bad.
The "look everywhere and memorize stupid trivia about random parts of the world for randomly picked questions" shtick to a puzzle where following all the clues to a logic puzzle doesn't eliminate all the wrong options.
Inventory management seems to be a bit more confusing than it needs to be because you need to collect and match a set of items in a machine to advance the plot. That means having items lying around in your inventory that may have a use in the machine, but might also have use elsewhere before then. And others just have no use at all other than to burden the strategy of trying every item on every item. And it's a big, generally connected world with a lot of locales where to try everything on everything.
And then there's the fish puzzle. Fuck the fish puzzle. Not even going to spoiler this. You need the sole, and it's for the plot machine. That's its only purpose. Fuck the other fish, they don't do fucking anything despite the game leading you on that they might be more desirable. Don't run around like an idiot for an hour looking for a use for your prize, thinking you might have missed something else. Get the sole, put it in the machine. Fuck.
So yeah. If it weren't for the voice acting, it's be a very lackluster game. If a live-action Christopher Lloyd making interesting remarks and quips in a cartoon world with recognizable voices doesn't appeal to you, then you should probably skip it.
If it does, get a guide, skip the aforementioned puzzles and enjoy the ride, I guess.