This is kind of an offshoot of the Doomer lit thread, but is not strictly limited to any medium:
ITT interesting doomeresque endtimes that aren't normie-tier (i.e. nukes, global warming, social apathy). I've seen some interesting ideas explored in various media:
>Year Zero (NIN album/multimedia project)
Human hubris and desire to control history inexplicably causes the appearance of a hand-like phantom, the vanishing of stars, and eventually the end of the world.
>The Stillness of The Wind (game by Fellow Traveler)
A community dissolves as younger people move out of the village and into the city; you play an old woman, the last one left, receiving increasingly disturbing letters from the people who moved to the city (admittedly have not finished this one yet, it's new, but mysterious events like all the birds suddenly disappearing see to point towards a behavioral sink style end of civilization looming over the urban populace)
I would say it doesn't have to be world-wide either, it can be localized like in Silent Hill. Sorry if I sound like a hard-r gamer, almost all the reading I do is nonfiction so I don't have much to draw from there. All my other examples are like Drakengard/Nier, Death Stranding, more vidya. Anything exploring unconventional ends of the world is interesting though, imo--even though the end will probably be our fault, i don't think anyone will be able to explain it scientifically, it will be unbelievable but true, we will know it s our fault but we don't know why.