Wanna know /christian/'s thought on this.
>Each of the villains closely resemble the Four Horsemen of the Apocalypse (John is Famine, Jacob is War, Faith is Death, and Joseph is Conquest), Joseph in particular has a crown symbolizing Conquest tattooed on his chest and Faith is strongly tied to White Lillies.
>Every time you kill a subboss, Joseph mentions that you've "broken another seal". Tied to this, are newscasts that very rarely play when you're listening to the radio (most people apparently never heard these) that start off benign, but the more villains (and the more seals you've broken), the more dire these newscasts become.
>Once you're down to the last two seals the newscasts will start mentioning things such as "Moscow being struck, death toll in the millions" and warning everybody to seek immediate shelter prior to your final encounter to Joseph Seed.
>The newscasts also mention disastrous weather across the country and world
>Joseph explicitly refers to you as "the Lamb"
>When you kill Faith she states, "Joseph believes he's our savior, but you'll be the one who decides. You were the start. You will be the end.", referencing Revelation 22:13
>In the opening scene, you can barely make it out, but there's a TV screen in the background that has the verse "They will wage war against the Lamb, but the Lamb will triumph over them because he is Lord of lords and King of kings–and with him will be his called, chosen and faithful followers." (Revelation 17:14)
>The main villain also shares aspects of the antichrist, as he's trying to deceive people into believing he's a prophet and a messiah
>The max amount of followers you can recruit are twelve, referencing the twelve apostles.
There's also aredditpost that explains more.
http://archive.is/Dwav8