>>14575807
Pretty much you're just limited to either creative layouts or games with limited inputs. I had a Naga for a period, I do not recommend, one of the worst mice I've ever had and the thumb grid was borderline useless, the thing randomly changed its tracking speed and if you had the polling rate too high it'd occasionally eat your whole CPU.
With Xpadder you can set toggles as well, so if you're not in high need of the joystick with specific inputs, for example, you can set up the dpad's directions to be 4 hotkeys, then BB+dpad for 4 more, and LT+dpad for 4 more, or you can set up cyclic sets that taps toggle through, though I found that to be pretty unreliable.
>>14575819
50/50. I had a Nostromo N50 I think it was, it's been a long time, it had a 3x5 grid of keys, a palm rest, a throttle, a thumb dpad, and a button by the dpad.
First problem is that it's hard to decide how to set the dpad up being that it's not sitting at a natural angle. I tried setting it so 'up' was forward and so that 'forward' was forward and neither felt right, I always found myself using the other tense moments and getting all screwed up, in the long run I never used the dpad.
The keys were plenty useful, and you could set up multiple key sets that could be toggled through or held with an assigned key or button to give you more hotkeys, kind of like shift/ctrl/alt sets, that worked well enough.
The throttle was useless in everything I tried it with.
In the long run just using a regular keyboard ended up working better, but if you're playing on a recliner or something I could see it being pretty useful to balance on the arm of the chair with less trouble than a whole keyboard.
The one I had had no problems with durability, I had it years though I didn't use it a huge amount.