Fist of the North Star is a bit more obscure than something like DBZ but it's still fairly normalfag friendly. I've noticed that some posters on other boards tend to think anime is "mainstream" but that's not quite true. I think that perception comes from people that are still in college or people that watch weeb youtubers, weeb streamers on Twitch, and hang out in cancerous dumps like anitwitter and faggy https://hooktube.com/watch?v=QN_6AZT92pU& servers.
In reality the average normalfag knows "of" anime but is rather indifferent towards it. Normalfags are still primarily interested in sportsball, substance abuse, and using social media to get themselves stuck up some roastie's ass during their free time to get laid. At my workplace I know of one weeb from the IT department that is a CR subscribing shonentard that no one likes. All the other nerdy types are mostly into Soy Wars, shitty AAA video games, and Marvel shit.
Strangely enough I've known a few rednecks and ex-military that had a thing for anime, granted most of it was entry-level stuff, but that's still kinda rare.