>>334288
Only some drugs work on dopamine, mostly stimulants. Not only that, but a huge amount of drugs work differently even if they operate on the same brain systems. MDMA and LSD both operate on parts of the serotonin system, but they're leagues apart in terms of effect.
Psychedelics in particular are an experience, not something you neccessarily do just to feel good (and indeed, they're drugs people take once a month tops for the most part). If euphoria is all you want, you'd probably be (ab)using cocaine or heroin.