Continuity and how much can you have in a series before it deters any new viewers from watching is probably one of the big questions when it comes to cartoons.
>Make something episodic with no continuity? (Eg: Dexter's Lab, Cow & Chicken) Anyone (of any age) can watch without fear of story lock out and what the networks probably want.
>Very minor character development and minor story arc progression in the background in a mostly episodic series? (Eg: season 1-3 of Rugrats). Same as above but also rewards long time viewers.
>Start off episodic for the first season but still with continuity than go into a good story arc for the next season with previous episode intro recaps (Avatar:TLA). Does give new fans a chance to catch up while still being a good for existing fans.
>Absolute fucking in depth densely packed fast paced story per episode, with NO previous episode recaps. Miss an episode any viewer (even fans) are fucked (Eg: Chris Colorado). In the 2000's this was a very bad idea and probably lead to the cancellation of that series, now probably less so with internet streaming to catch up with missing episodes but still be a strong deterrent to most people
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I think there is a blog post out there from Rob Renzetti who was pissed off at Nick for not showing episodes of his show My Life as a Teenage Robot in order after they made the 2 part special Escape from Cluster Prime. Leading to the question of, why bother making multi part episodes if the network won't show them in the proper order?